Difference Between Glucose and Fructose

The Key Difference Between Glucose and Fructose is that Glucose is a monosaccharide and one of the major sources of energy for living organisms. Fructose is a simple sugar widely used in foods and beverages. To understand the difference between glucose and fructose better, it is important to know the chemical structure of both of these molecules.

What is Glucose?


Glucose is a monosaccharide that is often referred to as a simple sugar. It is a very important compound in chemistry and a vital compound within our bodies. It also comes in many different isomers, so understanding how it works will help you understand things like corn syrup and maple syrup.

Glucose is a monosaccharide that is perhaps one of the most important compounds within the field of chemistry. It is a vital compound within our bodies, our energy source.

The most important monosaccharide is glucose, which is the body’s preferred source of energy. Glucose is also called blood sugar because it circulates in the blood and relies on glucokinase or hexokinase enzymes to initiate metabolism.

Your body processes most of the carbohydrates you eat by converting them into glucose. It is for immediate use as energy or for storage in muscle cells and liver as glycogen for later use. Unlike fructose, insulin is released primarily in response to high blood sugar levels, but insulin promotes the entry of glucose into cells.

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Glucose is absorbed directly into the bloodstream from the inner lining of the small intestine and transported to the cells (4Trusted Source, 5TrustedSource).

It raises blood sugar faster than other sugars and stimulates the release of insulin (6TrustedSource).

Insulin is needed to enter glucose into cells (7TrustedSource).

Once inside the cell, glucose is immediately used for energy or converted to glycogen and stored in the muscles and liver for future use (8Trusted Source, 9TrustedSource).

Your body controls your blood sugar. When they become too low, glycogen is broken down into glucose and released into the bloodstream for energy use (9TrustedSource).

If glucose is not available, the liver can make this type of sugar from other fuel sources (9).

What is Fructose?


Fructose is a monosaccharide and a simple ketone. Usually, saccharides are called sugars, and oligosaccharides are called complex sugars. It is also found in honey and fruits. It is commonly used as a sweetener for food. Fructose is also known as aldose.

The most important property of fructose is that it is a pentose aldose. It has a formula C(6)H(12)O(6). It contains five carbon atoms and it is a ketone.

Fructose is a sugar naturally found in many fruits and vegetables and is added to a variety of beverages such as sodas and fruit-flavored drinks.

However, it differs significantly from other sugars because it has a different metabolic pathway and is not the best source of energy for the muscles and brain.

Fructose is metabolized only in the liver and relies on fructokinase to initiate metabolism. It also produces more fat or fat than glucose.

Unlike glucose, it does not cause insulin release or stimulate the production of leptin, an important hormone that regulates energy intake and consumption.

These factors raise concerns about a chronically increased dietary fructose intake, as they appear to behave more like fat in the body than other carbohydrates.


  • Because sucrose is a disaccharide, it must be broken down before the body can use it.
  • Oral enzymes break down some of the sucrose into glucose and fructose. However, most sugar digestion occurs in the small intestine (4TrustedSource).
  • The enzyme produced in the inner lining of the small intestine is broken down by sucrose into sucrose into glucose and fructose. It is then absorbed into the bloodstream as described above (4TrustedSource).
  • The presence of glucose increases the amount of fructose absorbed and also stimulates the release of insulin. This means that more fructose is used to produce fat compared to eating this type of sugar alone (13).
  • So eating fructose and glucose together may be more harmful to your health than eating them separately.
  • This may explain why added sugars such as high fructose corn syrup are associated with a range of health issues.

Major Difference Between Glucose and Fructose

  1. Fructose and glucose are monosaccharides with the same chemical composition but different molecular structures.
  2. Both sugars are found in some blends of almost all available sweeteners.
  3.  Glucose requires insulin for proper metabolism and does not require the conversion of insulin to fructose.
  4.  Crude fructose is many times sweeter than glucose
  5. Glucose is a rich source of energy for the body. They are aldoses because they are both aldoses and hexadecimal numbers. Fructose is sweeter than glucose. They are ketosis and ketosis as exposure.
  6. Glucose, corn sugar, glucose, blood glucose, and glucose is also known as D-fructose; fructose, fructose, D-fructose furanose, D-arabinose-hexose, and D-fructose are also called fructose.
  7. The IUPAC name is glucose 2,3,4,5,6-pentahydroxyhexanal and the IUPAC name is fructose 1,3,4,5,6-pentahydroxy-2-hexanone.
  8. Glucose is produced commercially by the hydrolysis of starch. However, because glucose is highly reactive, it is not stored in animals or plants, but it acts as an energy source in the form of glycogen, starch, lactose, sucrose, and cellulose.
  9. Fructose is naturally obtained from flowers, fruits, trees, honey, and grapes, while fructose is commercially produced from corn, sucrose, and sugar beet.
  10. Glucose has a high glycemic index, produces less fat, and produces less fat. Conversely, fructose has the lowest glycemic index of all-natural sugars, produces more fat, and is more lipogenic.
  11. Glucose is difficult to dissolve in water. Fructose, on the other hand, is the most soluble of all sugars.


By consuming protein and fat, you can get the energy you need. It is said that 1 gram of carbohydrate contains about 4 kcal (kcal) and 1 gram of fat contains 9 kcal.

Our brain needs energy to function properly, but neurons are given in the form of glucose because they cannot burn fat.

However, you should keep in mind that high sugar intake or calorie-containing forms such as glucose and fructose can lead to weight gain.

Carbohydrates continue to be an important part of the human diet. However, it is advisable to “avoid carbohydrates and fats”.

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